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KMID : 0624620150480060336
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BMB Reports
2015 Volume.48 No. 6 p.336 ~ p.341
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Anti-septic activity of α-cubebenoate isolated from Schisandra chinensis
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Kook Min-Soo
Lee Sung-Kyun
Kim Sang-Doo
Lee Ha-Young
Hwang Jae-Sam
Choi Young-Whan
Bae Yoe-Sik
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Abstract
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Sepsis is a life-threatening, infectious, systemic inflammatory disease. In this study, we investigated the therapeutic effect of α-cubebenoate, a novel compound isolated from Schisandra chinensis against polymicrobial sepsis in a cecal ligation and puncture (CLP) experimental model. Administration of α-cubebenoate strongly enhanced survival in the CLP model. α-cubebenoate administration also markedly blocked CLP-induced lung inflammation and increased bactericidal activity by enhancing phagocytic activity and hydrogen peroxide generation in mouse bone marrow-derived macrophages and neutrophils. Expression of two important inflammatory cytokines, IL-1β and IL-6, was strongly increased in the CLP model, and this was dramatically blocked by α-cubebenoate. Lymphocyte apoptosis and caspase-3 activation, which are associated with immune paralysis during sepsis, were markedly attenuated by α-cubebenoate. Taken together, our findings indicate that α-cubebenoate, a natural compound isolated from Schisandra chinensis, is a powerful potential anti-septic agent.
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KEYWORD
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α-Cubebenoate, Apoptosis, Bactericidal activity, Inflammation, Sepsis
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